The MPC&A Program is comprised of four complimentary divisions:
- The Office of Nuclear Warhead Protection  works with various organizations of the Russian Ministry of Defense, including the 12th Main Directorate (the organization responsible for nuclear munitions), Navy, and Strategic Rocket Forces.
- The Office of Weapons Material Protection  upgrades systems at Russian Federal Atomic Energy Agency (Rosatom) weapons facilities.
- The Office of Material Consolidation & Civilian Sites  conducts upgrades at civilian nuclear facilities throughout Russia and works with other key partner countries on nuclear security best practices.
- The Office of National Infrastructure & Sustainability  assists the Russian Federation to develop and maintain a nation-wide MPC&A infrastructure.